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Re: Johnson + Johnson vaccine can someone explain how

Posted by alexandra_k on May 29, 2021, at 6:01:03

In reply to Re: Johnson + Johnson vaccine can someone explain how, posted by alexandra_k on May 29, 2021, at 5:46:07

It sounds like they don't know.

in the J&J and other DNA viruses DNA is delivered into the nucleus. The DNA is a short fragment (not a whole chromosome or anything). It is capable of being translated into mRNA and the mRNA is capable of making a fragment of the spike protein found on the outside shell of Coronavirus which is recognised as an antigen by the body.

I think we don't know how long that DNA fragment lives inside the cells nucleus.

It is capable of doing a 'jumping gene' thing and permanently getting inside the DNA? Maybe. Which cells in particular does the DNA get inside, anyway? All the cells? Or just a few from the respiratory tract... I don't even know that.

Plasmids are a bit different. Bacteria don't have compartments. Their DNA is in the cytoplasm and they make protein from mRNA in the cytoplasm. Animal cells are different where the DNA is contained inside the nucleus and the proteins are made (and folded) in a protected compartment the endoplasmic reticulum...

People don't have plasmids... Little circuluar bits of accessory DNA... I don't know... We don't know..

Likely it is degraded.

I guess they will want to be measuring the blood to see teh levels of spike protein that are being produced by the body to see for how long the DNA is being made into mRNA and protein by the body, anyway. But that doesn't tell us whether or not it has been degraded by teh cell, I suppose. I don't know. LIkely it makes mRNA until it's worn out / degraded. I don't know.




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