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SSRIs with atypical antipsychotics

Posted by undopaminergic on May 25, 2021, at 6:34:44

Researching asenapine, I came across this:
Title: "Adjunctive treatment with asenapine augments the escitalopram-induced effects on monoaminergic outflow and glutamatergic neurotransmission in the medial prefrontal cortex of the rat".

Quote: "The present study shows that addition of low doses (0.05 and 0.1 mg/kg) of asenapine to escitalopram (5 mg/kg) markedly enhances dopamine, noradrenaline, and serotonin release in the rat mPFC as well as dopamine release in the nucleus accumbens.".





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