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Re: Attn: Linkadge(?) Can you elaborate on this study? undopaminergic

Posted by linkadge on May 22, 2021, at 8:34:09

In reply to Re: Attn: Linkadge(?) Can you elaborate on this study?, posted by undopaminergic on May 21, 2021, at 3:19:24

I suppose it is a matter of dose, but the reason I say this is .....

At a similar of DAT inhibition, cocaine causes more dopamine release than ritalin. Some of this effect can be blocked by 5-ht1b receptor antagonists. When you add serotonin reuptake inhibition to ritalin, you get a greater degree of dopamine release, via stimulation of 5-ht1b receptors in the NAC. Cocaine is a triple reuptake inhibitor whereas ritalin does not have any effects on the serotonin transporter.

Also in studies on addiction related genes (i.e. intermediate early genes / cfos), you notice a much more significant activation with cocaine than ritalin. Interestingly, adding a serotonin reuptake inhibitor to ritalin produces a more 'cocaine like' profile in terms of activation of addiction pathways.

That being said, if you took a dose of ritalin that produced higher DAT inhibition, the effects could be more similar.





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