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Re: Attn: Linkadge(?) Can you elaborate on this study?

Posted by undopaminergic on May 21, 2021, at 3:19:24

In reply to Re: Attn: Linkadge(?) Can you elaborate on this study?, posted by linkadge on May 20, 2021, at 17:42:00

> As to whether it decreases the (possible) addictive effects of ritalin is unclear (but would seem logical). Ritalin also activates the reward system, but to a lesser extent than cocaine.

I'm not sure about that (lesser extent than cocaine). I think the difference may be attributed to the route of administration. Ie. cocaine is rarely taken orally. Injected methylphenidate has pretty much indistinguishable effects from cocaine, and the main difference is the shorter half-life of cocaine, meaning it's possible to re-dose it more freqently than methylphenidate and still get a high.

Cocaine is also a serotonin reuptake inhibitor, which means it would be expected to decrease dopamine release through increased agonism at serotonin 5-HT2C receptors.

> Ritalin's actions are complex.

Not as complex as those of cocaine.

> [Ritalin] may have additional effects that go beyond increasing dopamine.

Yes, it is also a noradrenaline reuptake inhibitor, like cocaine.

Does it also bind to other receptors/sites?





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