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Re: lamictal

Posted by rjlockhart37 on April 9, 2021, at 14:14:15

In reply to Re: lamictal, posted by rjlockhart37 on April 6, 2021, at 0:22:10

I dug up some info

https://go.drugbank.com/drugs/DB00555
"
"Lamotrigine likely acts by inhibiting sodium currents by selective binding to the inactive sodium channel, suppressing the release of the excitatory amino acid, glutamate"

. "In laboratory binding assays, it demonstrates weak inhibitory effect on the serotonin 5-HT3 receptor. Lamotrigine also weakly binds to Adenosine, adrenergic receptors, dopamine D1/D2 receptors, GABA A/B receptors, histamine H1 receptors, κ-opioid receptor (KOR), mACh receptors and serotonin 5-HT2 receptors with an IC50>100 ÁM. Weak inhibitory effects were observed at sigma opioid receptors.14 An in vivo study revealed evidence that lamotrigine inhibits Cav2.3 (R-type) calcium currents"



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poster:rjlockhart37 thread:1114376
URL: http://www.dr-bob.org/babble/20210120/msgs/1114483.html