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Irreversable MAOI + Buspirone, anyone?

Posted by Psy-Naught on February 22, 2021, at 1:10:37

I haven't searched too deeply yet, but most sites warn against MAOIs + buspirone (Buspar). Not because of Serotonin Syndrome but cos of the risk of increased blood pressure with the possibility of hypertensive crises risk.
We know general primary care and what it plasters all over the web is over exaggerates a lot. I was just wondering if anyone on here has used an MAOI with buspirone safely, and with which MAOI?
I'm already taking 35mg of dex, 300mg bupropion, 4mg clonazepam, 100mg amitriptyline & 100mg quetiapine. 300mcg melatonin at night. Several noots too.
My MAOI is isocarboxazid 90mg. No problems with my current mix at all.
If it is blood pressure that is a real problem, I could ask my doc if I could switch the bupropion to a specific NRI. NRIs are more commonly recognized to have the ability to block pressor response. Actually, the 1st study I read what nearly 20 years ago, where reboxetine was shown to prevent the pressor response of tranylcypromine + tyramine. Perhaps the bupropion would even be enough, with its higher than moderate noradrenaline reuptake abilities?
Any input would be appreciated. Anecdotal accounts aren't much good for my doctor but I take them seriously, especially here.
Hope you are all taking care. The world has gone way beyond crazy now...

Major Depression, Social Phobia, Agoraphobia, ADD.
Isocarboxazid, bupropion, amitriptyline, dexamfetamine, clonazepam, quetiapine + noots, supps and things.




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