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Re: Suggestions on treating Tardive Dyskinesia TD? jay2112

Posted by undopaminergic on November 7, 2020, at 3:22:33

In reply to Re: Suggestions on treating Tardive Dyskinesia TD?, posted by jay2112 on November 6, 2020, at 17:09:40

> > > Propranolol, Amantadine, and clonidine.
> >
> > Amantadine sounds interesting. I would be concerned that clonidine would cause depression.
> >
> >
> > - Scott
> I found amantadine to have a good antidepressant quality. Not as robust as the standard stimulants, but works well in a mix with antidepressants and a stimulant. May work well against t.d. I actually found amphetamine to be a good med to fight t.d. (Even though it is a suspected cause.) Yes, clonidine does have that depression-inducing quality, but in small doses, I found it useful for akathisia. That is the most intolerable aspect of EP symptoms, for me, anyway.
> I was also thinking, amitriptyline has a strong anti-cholinergic profile, which may be also effective for depression. But, treatment response vs. side effects. Hmmmm..

Amantadine can also augment antidepressants in animal models of depression.

It may have been the trigger for an intense hypomanic episode I had in late 2007 to early 2008.

Memantine can be a stronger alternative to amantadine. Structurally, these agents are very similar; memantine is dimethyl-amantadine.





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