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Re: How does trimipramine (Surmontil) work?

Posted by undopaminergic on October 10, 2020, at 2:56:38

In reply to Re: How does trimipramine (Surmontil) work?, posted by linkadge on October 9, 2020, at 15:25:35

> Muscarinic receptor antagonism, 5-ht2 receptor antagonism and possibly some other actions (ion channels, inflammation). There could be other actions like epigenetic modifications which go beyond the monoamines. It may also regulate the HPA axis independently of the above actions.
> Who knows.
> Linkadge

You're right, it *is* an ion-channel antagonist. It numbs the mucous membranes of the mouth.

It may be relevant that famotidine (another histamine-H2 antagonist) has been used with some success for schizophrenia, the negative symptoms of which resemble depression:





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