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Re: Trintellix for rage disorder? cadburyhesychasm

Posted by SLS on October 11, 2019, at 20:20:41

In reply to Trintellix for rage disorder?, posted by cadburyhesychasm on October 11, 2019, at 13:20:05

Hi, Cadburyhesychasm.

> Do you think following the theory of 5-ht1b heteroreceptor activation attenuating aggression, vortioxetine might work for my intermittent explosive behaviour (destruction of property, screaming, official diagnosis schizoaffective but just rage and depression). Is it a partial agonist at that receptor, meaning the dose must be kept low or it starts to have antagonist instead of activating effects? if so what dose do you think might be suitable to keep the receptor activated sufficiently?

Linkadge gave very informed and insightful answers - as usual. I wasn't aware that lithium blocks 5-ht1b autoreceptors. That might explain the many reports over the years that describe increased serotonin release with lithium.

Of the anticonvulsants, carbamazepine (Tegretol) is the one that I have seen described most often as being effective for Intermittent Explosive Disorder, rage, and aggression. It made a big difference for a friend of mine. However, I think you should take a look at oxcarbazepine (Trileptal) first. It is a sister drug of carbamazepine, but is less sedating and does not require regular blood tests to monitor for agranulocytosis. There are fewer studies of oxcarbazepine, but some of them have reported good results.

My friend stopped taking his carbamazepine because he didn't want to spend money on it anymore. His wife had to go to court to get a restraining order.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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