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Nicotinic ACh receptors drugs and dep/rage

Posted by cadburyhesychasm on September 1, 2018, at 3:11:00

I have reactive rage disorder with comorbid depression, no clear diagnosis except schizoaffective possibly, personally don't agree with it. I have catastrophic rage, destruction, screaming, profound irritability at minimal provocation, along with tearful griefy depression w sensitivity. Only drug that works is Risperidone somewhat and that only if I take a gram of Divalproex CR with it. Unfortunately tried many other neuroleptics, anxiolytics, beta blockers, antidep (raise symptoms), anticonv. drugs (unfortunately none work for me), and I can't tolerate the two drugs I'm taking. Hence, the need to go experimental. Now, I have read interestingly that acetylcholine is implicated in aggression and modulation of nicotinic receptors has effects on dep and aggression in various neuropsych disorders.
One article is here:
Now I'm not quite sure the take home points except that partial agonist of a4b2 receptor and antagonism of a7 nAchR might help. So I would like to know if anyone can help, is there more research on what can help the symptom and what safe drugs might help that act on the nicotinic receptors (I'm in India). Thanks for your help.




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