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Clomipramine For Social Anxiety

Posted by farshad on August 28, 2018, at 16:13:23

Hello, after looking around for a while, I have found a drug I think would greatly benefit my social anxiety.
Mainly becuase it reduces CRH (corticotropin-releasing-hormone).
Anyhow has anyone had success with this for social anxiety?

questions about studies:

According to this study:

1. ''It was found that clomipramine lowers CRH mRNA expression in the PVN by 74%''
Lowers MRNA expression? is that the same as decreasing the activity of CRH?
the study was done on syrian hamsters but supposedly they are similar to humans so it would work the same. I wonder why they used the term ''lower'' , in my mind lower is usually used to describe height etc, why they didnt use decrease MRNA expression, just curious.

2. according to this study
''st johns wort given daily by gavage for 8 weeks but not for 2 weeks significantly decreased levels of corticotropin-releasing hormone (CRH) mRNA by 16-22% in the hypothalamic paraventricular nucleus (PVN''
So would combining clomipramine + st johns worth = decrease CRH activity up to 96%?

3. this study:
''After beginning treatment with clomipramine, there was a significant decrease in CSF levels of CRH''

what is cerebrospinal fluid is it connected to the hypothalamus PVN and will decreasing CRH there affect your mood?




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