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valproate, lamotrigine and carbamazepine

Posted by farshad on August 3, 2018, at 13:37:09

hi ive tried many different meds none which worked and these type of class drugs i have yet to try but i heard they can used to get a stable mood. I looked some studies and these 3 have CRH inhibitions effects which is what im looking for.
has anyone tried either of these 3 for anxiety?

Studies i copy n pasted text:
''Valproate (depakote) decreased CRH release in rats also decrease CRF1 binding in the amygdala and hypothalamus , whereas lamotrigine stabilized ACTH/cortisol secretion. Moreover, felbamate was found to inhibit stress-induced corticosterone release in mice. Interestingly, recent data suggest that felbamat and some other new antiepileptic drugs may inhibit transcriptional activity of glucocorticoid receptors. Summing up, the above data suggest that traditional antiepileptic drugs may cause endocrine disturbances, especially in gonadal hormones.

Carbamazepine (CBZ) is a widely used therapeutic agent in seizure, pain, and mood disorders. Although CBZ has been shown to inhibit hypothalamic CRH .''




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