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Re: How can I block Cortisol?

Posted by farshad on March 19, 2018, at 14:16:15

In reply to Re: How can I block Cortisol?, posted by farshad on March 19, 2018, at 14:13:05

> has anyone seen this study ? its from 1998 . I think they are suggesting there could be CRF1 mutations but unrelated to cushings disease>
> I quote from the study ...No mutations affecting the CRF1-R protein have been found in all tumors analyzed. However, we found a significant overexpression of the CRF1-R messenger RNA in ACTH-secreting pituitary adenomas vs. inactive adenomas and normal pituitaries. We conclude that mutations of the CRF1-R are unlikely to be involved in Cushing's disease. We suggest that the overexpression of the CRF1-R messenger RNA may be related to a disturbed receptor regulation in ACTH-secreting pituitary adenomas...
> English is my 3rd language so maybe someone can explain this that understands it better_

I found 2 possible mutations that I have related to ACTH>


ACE (Angiotensin I converting enzyme)




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