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Re: Hypotension, MAOI's, and Moclobemide crazyvash

Posted by SLS on September 13, 2015, at 6:25:56

In reply to Hypotension, MAOI's, and Moclobemide, posted by crazyvash on September 12, 2015, at 22:18:49

I believe that:

1. Moclobemide poops-out 90 percent of the time, leading to a constant escalation in dosage to 1200 mg/day without continued relief.

2. Moclobemide binds to MAO-A very tightly, even though it dissociates. One still needs to pay attention to the intake of tyramine. No more than 50 mg of tyramine should be consumed at one meal.

3. Moclobemide can make depression worse, although this does not occur in a great percentage of people. In this way, it really is no different from other antidepressants.

4. If moclobemide does work for you, it usually does not produce sexual side effects or weight gain.

5. I am not aware of hypotension being a problem with moclobemide in the majority of cases. It might be, but I am just not aware of it. I experienced no dizziness at all.

Have you tried Abilify, Saphris, or Geodon? Despite the indication of Seroquel for bipolar depression, I have never seen it work robustly or for very long.

You might want to explore a treatment regime similar to:

- Trileptal for the hypomania / mixed-state.
- Lamictal for the depression.
- Abilify, Geodon, or Saphris for residual depression and perhaps more protection against mania.

Of course, you would want to work closely with your doctor on this, but I don't see any contraindications for this combination.

* Despite many years of trying, Roche was unable to get the U.S. FDA to approve moclobemide. Roche even tried to get it approved for social anxiety instead. It didn't work in clinical trials, so Roche abandoned the project.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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