Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: does lamotrigine cancel out dexedrine? dopamine77

Posted by SLS on July 16, 2015, at 8:59:35

In reply to does lamotrigine cancel out dexedrine?, posted by dopamine77 on July 16, 2015, at 7:09:52

> I'm wondering if lamotrigine cancels out Dexedrine's effects?

Probably not.

I don't know for sure. However, it is my guess that lamotrigine reduces activity in the glutamate circuits that suppress dopaminergic activity in the nucleus accumbens, an important reward /pleasure and motivation center of the brain. Through a process known as disinhibition, lamotrigine ends up increasing dopamine, not lowering it.

It is only my guess that amphetamine would not cancel-out lamotrigine. I did not lose the positive effects of lamotrigine by adding amphetamine or lisdexamfetamine. Actually, adding dexmethylphenidate (Focalin) gives me more energy and a slight improvement in mood when combined with lamotrigine. I don't like to use it except for emergencies when I have to function better. I don't want to build up a tolerance to or a reliance upon it.

By the way, adding Abilify to lamotrigine can help to activate limbic structures without producing subsensitization like Mirapex would.

> I know that lithium and divalproex does.

I hadn't heard that. Do you know where in the brain this occurs? To my surprise, I discovered that valproate can actually increase dopamine activity in the pre-frontal cortex (thinking linked to mood), although not in the nucleus accumbens (mood).

Has anyone recommended that you try to combine lamotrigine with NAC (N-acetylcysteine)? I might try doing this in a few weeks if I get stuck.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:1080542
URL: http://www.dr-bob.org/babble/20150629/msgs/1080543.html