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Re: Indivduals w social phobia have too much serotonin Hugh

Posted by SLS on June 22, 2015, at 12:30:19

In reply to Re: Indivduals w social phobia have too much serotonin SLS, posted by Hugh on June 22, 2015, at 10:48:29

> I'm unipolar. Clomipramine made it very difficult for me to concentrate. Trazodone made me groggy. Nefazodone made me very irritable. Buspirone caused suicidal ideation. All of them made my heart race. Mirtazapine helped me sleep, and it lessened my depression and anxiety somewhat. I think this was because it's an antihistamine. Selegiline also lessened my depression somewhat, but I gave it up because it was overly stimulating. I tolerate stimulants very poorly.
>
> Of all the things you mentioned, what interests me the most is 5-HT7 antagonism.

The ones that I am aware of are Latuda, Abilify (partial agonist), Brintellix. and Risperdal. What other ones are you looking at?

I don't know how accurate this is:
https://en.wikipedia.org/wiki/5-HT7_receptor#Antagonists

How does 5-HT7 antagonism help with depression?

- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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