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Re: Viibryd and Brintellix might be better as adjuncts joe f

Posted by SLS on June 15, 2015, at 11:50:06

In reply to Re: Viibryd and Brintellix might be better as adjuncts, posted by joe f on June 15, 2015, at 6:45:45

> very few posts ever about viibryd

I'm not sure why that is. I guess doctors are not very impressed with it. Viibryd produced a mild improvement for me that lasted for about a week. I don't think the drug is completely inert.

For Viibryd and Brintellix:

1. Is the dosage used high enough?
2. Is the time allowed for treatment long enough?
3. Is it better used as an adjunct to other drugs?

I don't know.

It should be noted that as a multimodal antidepressant, Brintellix is a full agonist at 5-HT1a receptors rather than a partial agonist. Partial agonist drugs include Buspar, Geodon, Latuda, Abilify, and Viibryd. My initial thought is that partial agonism might be better than full agonism when treating depression, as it might act like a serotonin system stabilizer. This would be analogous to Abilify, a dopamine D2/3 receptor partial agonist that acts as a dopamine system stabilizer. Full agonism at dopamine receptors are not generally as helpful for depression as is Abilify.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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