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Re: Medications that don't touch the 5HT1 receptor? phidippus

Posted by SLS on June 14, 2015, at 19:43:28

In reply to Re: Medications that don't touch the 5HT1 receptor? SLS, posted by phidippus on June 14, 2015, at 16:49:11

This is a bigger issue than I wish to address again. It takes too long.

If you are indeed an ultradian rapid cycler, then you should fully appreciate the potential for the brain to switch affective states over the course of hours. Why shouldn't a drug be capable of provoking a similarly rapid change in mood upon its introduction as a time-limited startup effect? And, yes, the occurrence of a transient improvement "blip" within the first week of treatment was considered to be a good sign of future response by the staff of the Department of Clinical Pharmacology at the NIMH.

What would happen if a postsynaptic neuron were subject to a sudden increase in neurotransmitter as facilitated by a reuptake inhibitor? What would happen to this same neuron as the concentration of neurotransmitter continued to rise and remained chronically high?. What happens to the rate of action potentials generated when a neuron remains depolarized? What must occur for this postsynaptic neuron to resume firing if the concentration of reuptake inhibitor remains constant? How long does it take for these events to occur?

Let me know what you come up with.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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