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Re: Medications that don't touch the 5HT1 receptor?

Posted by SLS on June 13, 2015, at 10:06:11

In reply to Re: Medications that don't touch the 5HT1 receptor? tiopenster, posted by phidippus on June 13, 2015, at 8:07:20

> >How soon do you experience tachyphylaxis (poop out) on a med? It would happen to me after 3 days on an ssri/tricyclic
>
> ADs typically take 4-6 weeks to start working.
>
> I would consider the placebo effect.

Certainly, everyone has their right to consider the placebo effect to explain tachyphylaxis. For some people, this might be true. However, for lots of people, it is not. Insisting on dismissing a patient's report of a transient improvement with medication can be confusing and belittling. It is insulting and displays ignorance of the variable phenomenology of biological mood disorders. Ever hear of ultradian rapid cyclicity? In the absence of medication, people with this presentation can complete a mood cycle between mania and depression within 24 - 48 hours without fail. I would not be inclined to call this a placebo effect, especially when someone presents this way as their untreated baseline as their index condition.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1079343
URL: http://www.dr-bob.org/babble/20150520/msgs/1079738.html