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Re: Medications that don't touch the 5HT1 receptor? tiopenster

Posted by SLS on June 13, 2015, at 0:01:23

In reply to Re: Medications that don't touch the 5HT1 receptor?, posted by tiopenster on June 12, 2015, at 21:39:50

I suffer from chronic bipolar depression with drug-induced psychotic mania. It is a variant of bipolar 1 disorder.

Regarding tachyphylaxis, if a drug is going to produce a robust improvement, I must be on it for 10 - 13 days before it emerges. My mood switches from depressed to euthymic within hours. Unfortunately, the improvement disappears just as rapidly after 3 days. The best I can do now is to take six drugs and maintain an inadequate partial improvement in mental energy. I once responded very well for over 6 months on a combination of Parnate 60 mg/day and desipramine 150 mg/day. Unfortunately, mania emerged and the antidepressants were discontinued. I relapsed into depression 2 months later. I no longer responded to treatment after that.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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