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Re: Medications that don't touch the 5HT1 receptor?

Posted by tiopenster on June 11, 2015, at 15:11:08

In reply to Re: Medications that don't touch the 5HT1 receptor? tiopenster, posted by phidippus on June 11, 2015, at 14:22:44

I've been on

neurontin (not effective),
depakote (not effective),
lamictal (somewhat effective),
lithium (not effective),
topamax (made me feel depressed)
lyrica (very effective, but poops out after a week)

abilify (not effective),
seroquel (akastisia),
geodon (effective, then dropped in effectiveness)
risperdal (not effective)
zyprexa (very effective at over 10mg, but made me gain 45 lbs and very very tired)

(all would make me feel perfect the first 2 to 3 days, but then would make me cycle - usually anxiety, normal, manic (only on lexapro), and sometimes depressed

Lexapro - made me crazy anxious and gave me panic attacks
Serozone - increased anxiety 10 fold
Cymbalta (cycling every few days
Paxil (same pattern)
Zoloft (same pattern)
Nortryptiline (same pattern)
Effexor (felt good immediately, but got a rash)
Buspar (same pattern)

Remeron (very effective, - similar to zyprexa. made me gain a lot of weight and turned me into a zombie

The cocktail that resolved my problems 2 years ago was the following, but I was a zombie that slept a lot and didn't talk much


I had gotten off Lamictal, Lyrica & Remeron. I got my geodon to 20mg but kept that dose for insomnia that would come from tapering off Klonopin. My anxiety came back after I had gotten down to .5mg of Klonopin after being on 2mg.

I am doing better on 225mg of lyrica and 50mg of Insidon (german medication). I'm back on 2mg of klonopin and still on 20mg of Geodon. I still need something more - i will most likely go up on the insidon.

The ones I do best on are the ones that don't touch my 5ht1 receptor - remeron and insidon. Zyprexa seems to be weak at the 5ht1a. Lyrics works 100% when i start it but then drops in effectiveness a week later (dose is irrelevant).

Any other suggestions would be great. I have looked at Trimipramine which doesn't touch that receptor either, but makes me incredibly zombie like the next day for anything over 50mg.




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