Psycho-Babble Medication | about biological treatments | Framed
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Re: Medications that don't touch the 5HT1 receptor? tiopenster

Posted by SLS on June 4, 2015, at 21:22:13

In reply to Re: Medications that don't touch the 5HT1 receptor?, posted by tiopenster on June 4, 2015, at 20:58:53

> I stay on the methylfolate because I feel much better on it. Helps the depression. I have the MTHFR genetic defect.
> I know that methylfolate and methyl b12 create all three neurotransmitters and I do great on that. That's why I wondered if I have a problem with the reuptake mechanism of the SSRIs
> I'm still doing well on the Insidon (Opipramol)
> I had to take north of 10mg of Zyprexa for anxiety relief, but I gained 45 pounds on it.

I know someone who had to take Zyprexa for chronic anxiety. It worked well, but he gained an unhealthy amount of weight. It was discontinued and substituted with promethazine (Phenergan). Promethazine was as effective as Zyprexa for this person.

5-HT1a receptor partial agonism might not create a problem if you are so sure that full agonism is problematic. Viibryd and Brintellix are potent serotonin reuptake inhibitors, but act as partial agonists at 5-HT1a. With DA D2/D3 receptors, partial agonism results in a balance between blockade and stimulation depending on synaptic DA concentrations. Perhaps 5-HT1a partial agonism acts as a modulator in the same way. In the presence of too much serotonin, a partial agonist would then work as an antagonist. You might consider combining Viibryd or Brintellix with Remeron, which, at higher dosages, blocks other serotonin receptors as well as boosts norepineprhine via NE alpha-2a antagonism.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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