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Re: Medications that don't touch the 5HT1 receptor? tiopenster

Posted by tom2228 on June 4, 2015, at 11:37:50

In reply to Re: Medications that don't touch the 5HT1 receptor?, posted by tiopenster on June 4, 2015, at 1:00:52

> It's not so crazy when you think that I react the same way to Lexapro, Zoloft, Cymbalta, Serzone, Buspar, Effexor, Paxil, Nortryptiline. I would feel great within 24 hours and then it would spiral out of control into increased anxiety, depression, manic or normal. Rapid cycling multiple times a day. The common thread in there is the 5ht1 receptor.
> I've confirmed this theory with Insidon (Opipramol) which doesn't affect 5ht1. I didn't feel great immediately, rather a slow and gradual response with it kicking in after about a week. We'll see if it holds, but that's how these meds are "supposed" to work. I would just like a medicine similar to this that I can buy in America.
> Zyprexa works for me, but makes me a zombie.
> Lyrica worked excellent for me for 2 weeks. 100% great, but then stopped working.
> Methylfolate worked 100% on any depression I've had, but the anxiety is tougher to treat (for me). I would really recommend anyone with depression trying Deplin of methylfolate. Could be a real game changer.

Concluding that the common thread along those medications is the 5-HT1 receptor is about as logical as concluding that the resounding similarity among the numbers 1-27 is the number 13. SRIs affect every type of serotonin receptor -- why are you fixated on 5-HT1? Just because you did not respond to the 5-HT1a receptor partial agonist Buspar doesn't mean it's that receptor. It means you do not respond to Buspar. Buspar also has other mechanisms of action as well as the idea that there is considerable individual variability among responses to different medications with similar modes of action. You are also neglecting that Remeron, Geodon, and Deplin, which you state you respond to, all affect the 5-HT1a receptor, either directly or indirectly. Opipramol has several pharmacological actions aside from it's lack of direct effects on the 5-HT1 receptor.

This kind of selective reasoning is common among people who attempt to defend their situations with intellectualism, whereby one fixates on perceptibly logical ideas to the extent that one loses sight of the big picture. This is highly understandable as you are attempting to make sense of our struggles with your symptoms and medications, but ideas like having it out for the 5-HT1 receptor are not helping you.

A better way to navigate the efficacy of medications is to observe and compare the degree of improvement of your symptoms as you gradually expose yourself to the situations and feelings that surround your difficulties in functioning. This requires work on your part and is going to be uncomfortable. Psyhiatric diagnoses do not exist in a vacuum and medications to do work on humans as they do in a Petri dish.

That being said, if Deplin works so well what is the issue then? Why not stay on it and find another way to manage the anxiety? I am on Deplin myself and find that it is quite helpful. I was without it for 3 days this week and had a relapse in my depression and anxiety that have since recovered.

What dose of Zyprexa were you taking? I experienced trouble with bluntedness at higher doses, but am now taking 2.5mg and find I feel less of a zombie than the depressed state of not being on it.

Have you tried MAOIs?




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