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Re: METHADONE + GRAPEFRUIT JUICE (AND OTHERS)

Posted by Alfred G Land on February 25, 2015, at 17:19:04

In reply to Re: METHADONE + GRAPEFRUIT JUICE (AND OTHERS) robbieboy74, posted by kingcolon on September 5, 2008, at 14:10:59

Modfanil induces CYP 3A4 which metabolizes methadone. Using modafinil on a regular basis will cause methadone to be metabolized much more regularly.

In my experience, 110 mg methadone HCl/day would last long enough that I could miss a day's dose without much problem.
After five or six days of 400 mg modafinil/day, methadone would wear off so quickly that I would be sick within 24 hours due to methadone abstinence syndrome.


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poster:Alfred G Land thread:846370
URL: http://www.dr-bob.org/babble/20150223/msgs/1077112.html