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Re: Why isn't there a transdermal patch for Nardil????

Posted by cybernut011 on February 24, 2015, at 16:20:57

In reply to Re: Why isn't there a transdermal patch for Nardil????, posted by damnthislife on August 23, 2013, at 7:54:50

Here is the response that I received from the Dr. who pioneered the EMSAM patch:

"You would not expect to avoid the tyrmamine interaction by giving a
non-selective MAOI like parnate or nardil or maplan in a patch. For
that selegiline is unique, as a type B MAOI at low concetrations and
an incresing MAO A inhibiotor at higher concentrations. Parnate, for
example inhibits MAO-A strongly at any blood concentrtion, and that's
the interaction with food problem.

And its not obvious that MAOIs other than selegiline would have other
advantages by patch, tho one doesnt know without trying; there is a
very different metabolic pattern with transdermal drugs, which might
be advantageoous or disadvantageous clinically.

Wish you luck.

Dr. B

>Dear Dr. Bodkin,
>Hope this email finds you doing well. I have a curious question and
>probably one you have answered many times before so please accept
>my apologies in advance if so, but what would be the problem with
>using a non-selective MAOI such as phenelzine or tranylcypromine in
>the patch form like to EMSAM? I am "atypical"/MDD and have responded
>better to MAOI's than newer meds, but the options are so limited.
>Thanks in advance for your time in my curiosity.
>Best Regards"

So apparently the patch with those still dosent allow cheese or other forbidden stuff to be consumed, and the drug companies wont spend the money on it unless they are almost certain that it is a hit for them.




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