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Re: Do u think 5HT directly effects emotions Lamdage22

Posted by phidippus on October 31, 2014, at 18:26:25

In reply to Re: Do u think 5HT directly effects emotions, posted by Lamdage22 on October 24, 2014, at 11:30:56

I think we're finding out more and more each day that different 5ht receptors effect the brain in different ways than we thought. Targeting certain 5ht receptors for agonism or antagonism can really change the effect of a drug. The newest antidepressants and atypical antipsychotics are agonizing and antagonizing many different 5ht receptors for therapeutic benefit.

NMDA is complex stuff and the therapeutic benefits of antagonizing or agonizing NMDA receptors remains unclear. We know that antagonizing NMDA can lead to unwanted effects such as hallucinations and depersonalized states. PCP, Ketamine, dextromathorphan and ethanol can all cause hallucinations and depersonalized states. Even NMDA antagonists we have developed for clinical use have these undesirable side effects, like Memantine. Do the benefits of NMDA outweigh the risk? Ketamine supposedly delivers fast relief from depression, but its effects last only a day or two and there are considerable side effects. Is anyone developing an NMDA antidepressant without the side effects? AstraZeneca was developing Lanicemine, but that ended in 2013. AZD6765, an NMDA receptor blocker is another being developed. GLYX-13 is being developed for IV administration and there is evidence to suggest that the NMDA receptor ligands can demonstrate rapid antidepressant effects. NMDA is an exciting thing to explore, but we still don't understand it.

Eric


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