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Re: Nardil or Marplan? tom2228

Posted by rose45 on June 3, 2014, at 18:55:35

In reply to Re: Nardil or Marplan?, posted by tom2228 on May 12, 2014, at 13:30:11

> I have been on all 3 and Marplan is my favorite.
> Marplan makes me feel like myself (it is supposedly good for depersonalization/ dissociative symptoms) and allows me to be more in touch with memories of how I've felt throughout the years.
> I consider Marplan to be the cleanest. In general I find it to be relatively low on side effects. Some do say that the other two have more "umph" for depression, but that's a matter of subjectivity.
> - Mechanism wise it is the closest to a pure MAOI
> --Nardil has effects on GABA transaminase and phenylethylamine as a metabolite;
> --Parnate is stronger on MAOI-B and has an effect on GABA-B;
> --Marplan has has less-pronounced effects on dopamine beta-hydroxylase and tryptophan metabolism, although it "feels" the closest to a pure MAOI)
> -whereas the other two can have sedation problems, Marplan seems to be neutral to some and activating to others (I find it pretty stimulating at 40mg and over)
> -Marplan lacks, or is more forgiving in terms of the afternoon sleepiness you speak about
> -Marplan tends to be weight-neutral (whereas Nardil is is known of weight gain)
> -Sexual side-effects are not as bad a Nardil in my experience
> -The insomnia is nowhere near the insomnia on Parnate, I've found.
Thank you Tom for the information. Im wondering how long were you on Parnate and Nardil, and why did you stop them ?

Are you currently on Marplan ? Do you need to take sleeping meds with it?

I was on Nardil for 23 years, until it stopped working. I managed to sleep most of the time without sleeping pills. I am now on parnate, which has helped get rid of the anxiety and depression, but I am also very tired on it, and have total insomnia and the sleeping pills are a problem, because here in the uk,gps are instructed not to give out sleeping pills for longer than a certain period.I went to see a new psychiatrist yesterday, who is supposedly an expert in maois, and he was surprised that i found parnate to be energising in that it causes insomnia, but at the same time, makes me so tired during the day. Here, on psychobabble, I have read several people who have similar experiences with parnate.

Also I have not put on weight with parnate, but I put on a lot of weight with nardil. I have read that marplan is more similar to nardil. Would you agree? Did it create weight issues for you?

I would really appreciate getting answers to the above, because I have to take the decision on whether to stop the parnate, and try marplan, and changing drugs involves so much pain and is so problematic, it would be nice to have an idea re. whether it would be worth it.




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