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Re: Switching from Abilify to Latuda

Posted by Bob on January 29, 2014, at 14:11:14

In reply to Re: Switching from Abilify to Latuda Bob, posted by SLS on January 29, 2014, at 14:02:00

> >
> > Latuda also seems to be causing fatigue and has totally crushed my sexuality -- not that it wasn't almost gone already with my base cocktail of nortriptyline and sertraline.
> >
> > I've tried adding Wellbutrin as well as Nuvigil but both don't have sustainable benefits for me.
> >
> > Bob
>
> That is not an optimistic report. :-(
>
> Why are you taking an antpsychotic?
>
> Have you tried Abilify?
>
> Right now, I am pleasantly surprised that I have not dropped off for having discontinued Abilify. I don't know. Perhaps Latuda is making an effective substitute. I am not feeling too much better, but I don't think I am feeling worse. I thought I needed the dopamine activation provided by Abilify when treating depression (DA D2/D3 partial agonist). I really thought that I would significantly relapse. It's still early yet, of course, but I am hoping for magic. Latuda is not a DA partial agonist, but it is a 5-HT7 receptor antagonist. Recently, this receptor has been the focus of interest in accounting for the antidepressant effects of Latuda.
>
> I hope you are experiencing a temporary setback. Who knows what your brain is up to. Have you ever tried Focalin for fatigue / brain fog? It helps me when my energy ebbs. If it is a good drug for you, you won't experience a depressive rebound when it wears off. For now, I am using it occasionally in place of caffeine. My doctor prescribed it to be taken on a daily basis in the hope that it will kick-start a robust antidepressant response. I want to see how Latuda treats me first.
>
> Please continue posting.
>
> Me:
>
> Parnate 100 mg/day
> nortriptyline 150 mg/day
> Lamictal 200 mg/day
> lithium 450 mg/day
> Latuda 40 mg/day
> prazosin 25 mg/day
> minocycline 200 mg/day
>
>
> - Scott
>
>
>


Don't take my report of response to mean anything for you. We are very different in terms of med tolerance and effect I believe.

I am trying to augment my nortriptyline/sertraline combination to kickstart my response. I have tried all the stim class meds, including dexmethylphenidate. They all have an unreliable and troublesome response for me. As time goes on it's getting to be less and less. This always happens with every single medication I have ever tried that worked for any amount of time. Nothing lasts anymore and things which initially provided a response in the past are proving less and less effective.

Bob


Nortriptyline: 225mg (as close to 150ng/ml as possible)
Sertraline: 75mg
Lurasidone: 40mg

 

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poster:Bob thread:1059698
URL: http://www.dr-bob.org/babble/20140123/msgs/1059900.html