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Re: akathisia on mirtazapine SLS

Posted by doxogenic boy on October 28, 2013, at 8:30:23

In reply to Re: akathisia on mirtazapine doxogenic boy, posted by SLS on October 28, 2013, at 7:25:24

> > > > have you tried trimipramine for sleep?
>
> I took trimipramine for a few months in an attempt to treat depression. I can't say that it helped with insomnia, as my baseline depression presents with hypersomnia. I took it in the morning. It did not make me feel at all sleepy or sedated.

Thanks for your response.
The first time I took trimipramine, I think it was 10 mg, I slept for 20 hours. I waked up a lot of times, but had no problems falling asleep again. It was only the first time it had this powerful effect on my sleep, but I think it still have some effect.

I also use quetiapine and agomelatine (and three other meds), could it be that trimipramine+quetiapine+agomelatine work synergistically for more and better sleep? My insomnia is definitely cured - I sleep for 11-12 hours when my sleep isn't interrupted by an alarm clock, and I feel good and not tired at daytime with so much sleep.

> > > You are reading my mind!
>
> > That was a nice compliment! Does trimipramine work for sleep for Parnate users, and is the combo safe?
>
> The combination is safe, and might act synergistically with Parnate to produce a more robust antidepressant response. You will just have to experiment with trimipramine to see if it addresses your needs.

Thank you for this information. I am satisfied with my current meds (see my signature) that have worked for 4 years, but it is good to know that there is an option I haven't tried if they ever should stop working. When I am depressed, I always has insomnia too.

> Can you list the sleep-promoting (hypnotic) drugs that you have tried so far?

oxazepam
flunitrazepam
zopiclone
zolpidem
clonazepam
chlorpromazine
levomepromazine
quetiapine
chloral hydrate
alimemazine
mianserin
trazodone
mirtazapine
trimipramine
Xyrem
(I got Xyrem for depression, but it didn't work.)

Here is my medication history 1994 - 2009:
http://www.dr-bob.org/babble/20090826/msgs/914853.html

> > What about Parnate + trimipramine + quetiapine?
>
> That sounds like an excellent strategy to help with both depression and insomnia. Trimipramine might not increase the time spent asleep, but quetiapine should. Trimipramine will, however, increase the quality of sleep by extending the time spent in slow-wave (delta-wave) sleep.

I have "periodic limb movements during sleep",

http://www.sleepfoundation.org/article/sleep-related-problems/periodic-limb-movements-sleep
it showed on polysomnography in an overnight stay in a sleep laboratory, but I was medication-free when that was done in 2005. Does trimipramine work for that sleep disorder too?

And do quetiapine add any risk of interactions to a Parnate+trimipramine combo?

- doxogenic


Earlier TRD/anxiety
300 mg tianeptine, 6 X 50 mg successfully since Oct 2009
20 mcg liothyronine
40 mg escitalopram
100 mg trimipramine
50 mg agomelatine
600 mg quetiapine


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poster:doxogenic boy thread:1052837
URL: http://www.dr-bob.org/babble/20131025/msgs/1053212.html