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Re: Drugs for Rages, in context of mood disorder BygoneBeSpade

Posted by doxogenic boy on September 30, 2013, at 7:20:46

In reply to Re: Drugs for Rages, in context of mood disorder, posted by BygoneBeSpade on September 30, 2013, at 5:46:47

> My question is can it be said for certain that such aggression is dopamine related?

No; I don't think it is possible to say for sure that it is dopamine related. Then he should have taken a dopamine blood test or a brain scan that showed such a correlation. As far as I know, there exist no such tests that are reliable.


>Also, iloperidone and aripiprazole made me very raging also? Is that a normal response to these drugs if he's correct?

I don't know if it is normal, but it is my guess that old neuroleptics such as haloperidol, perphenazine, chlorpromazine, levomepromazine, zuclopenthixol and chlorprothixene may work better against aggression than atypical antipsychotics. The old neuroleptics have horrible side effects though, especially akathisia, which can lead to suicide.

You can find out about mode of action for psychiatric drugs here:
http://www.psychotropics.dk/Search%20Psychotropics/defualt.aspx

Did you ask your doctor about lithium, and if so, what did he say? I think lithium is the best drug against aggression. And lithium has the best evidence for neuroprotective effects, and it increases BDNF.

http://www.researchgate.net/publication/7313048_Effects_of_mood_stabilizers_on_hippocampus_BDNF_levels_in_an_animal_model_of_mania/file/79e41508589a996f4a.pdf

>It is true though that I do not understand this rage and the constant irritation in my head. I certainly have no reason to be angry. Maybe the violent childhood situation in my house affected my brain?

That is possible. The brain is affected by all stimuli.

>He says he's certain that though I have a mood
disorder of depression, the anger comes from
excess dopamine and not any sort of mania. (It's
funny how the doc can tell so much after just a
few visits).

I don't think it is possible to tell that without blood tests or a brain scan.

- doxogenic


Earlier TRD/anxiety
300 mg tianeptine, 6 X 50 mg successfully since Oct 2009
20 mcg liothyronine
40 mg escitalopram
100 mg trimipramine
50 mg agomelatine
600 mg quetiapine


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URL: http://www.dr-bob.org/babble/20130930/msgs/1051454.html