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Re: ECT In Kids, Safe,Effective But Under utilizied linkadge

Posted by SLS on July 3, 2013, at 10:09:45

In reply to Re: ECT In Kids, Safe,Effective But Under utilizied SLS, posted by linkadge on July 3, 2013, at 7:23:46

> No, but what is wrong with just ketamine?
>
> In all the clinical trials I have read, patients do not develop any significant 'psychotic' reactions.
>
> These companies likely want $$.
>
> Linkadge


These Naurex drugs are partial agonists at the glycine site of the NMDA receptor rather than being complete channel blockers like ketamine. I doubt there is a narrow therapeutic window to worry about. If you take even a little too much ketamine, you forfeit the antidepressant effect. Of course, taking a pill is more convenient than administering an i.v. drip. As an aside, i.v. administration of ketamine is probably necessary to deliver such a precise dose. Injections and nasal sprays can't do this, and I doubt these methods can hit the narrow window necessary to promote an antidepressant response.

I don't care if they want $$. Just give me my drugs.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1046274
URL: http://www.dr-bob.org/babble/20130617/msgs/1046337.html