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Re: Buy enteric capsules for nardil jono_in_adelaide

Posted by Tomatheus on March 25, 2013, at 13:11:24

In reply to Re: Buy enteric capsules for nardil, posted by jono_in_adelaide on March 25, 2013, at 1:37:52

> Nardil was sugar coated, not enteric coated, until the formulation change
>
> Source: William R Warner data sheet for Nardil, dated 1986

Did the fact sheet say that Nardil wasn't enteric coated, or did you make that part up?

The FDA (2002) stated this in a review document pertaining to the formulation change: "The current tablets are sugar coated. The tablet core is sealed with a coat of pharmaceutical glaze (shellac) prior to applying the sugar coating."

As I mentioned in the post that I linked to earlier, pharmaceutical glaze, or shellac, is an enteric coating material. It is water-insoluble at low pH levels and water-soluble at high pH levels (Pearnchob et al., 2004)

Tomatheus

==

REFERENCE

Pearnchob, N., Dashevsky, A., & Bodmeier, R. (2004). Improvement in the disintegration of shellac-coated soft gelatin capsules in simulated intestinal fluid. Journal of Controlled Release, 94, 313-321. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/14744483

U.S. Food and Drug Administration. (2002). Office of Clinical Pharmacology and Biopharmaceutics review (NDA 11-909/SCM-032). City of publication not available: Author.


Dx: schizoaffective disorder

Treatments: Abilify & Chinese ginseng

tomatheus.blogspot.com


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