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Re: is a GABA antagonist what i need? phidippus

Posted by AlexCanada on September 13, 2012, at 17:10:40

In reply to Re: is a GABA antagonist what i need? AlexCanada, posted by phidippus on September 12, 2012, at 17:13:11

ty for the suggestions. they are much appreciated.

I been trying to convince my doctor regarding memantine. i only been able to find one other study which states 30-40mg doses can help with MDD. Do you have any other possible sources?

I may just end up ordering it. And will definitely look into the others.

Dexedrine and ritalin I have tried. They worked exceptionally well but not in the long term. Much tolerance build up.

Modafinil I have tried. Short term works well for cognition drive motivation energy productivity but very mildly for actual ability to ''enjoy'' anything. It sometimes makes me feel empty, especially several hours after taking a dose and even can make me feel a bit sad and very procrastinated, non reactive. This may be a modafinil crash. It's a very perplexing medication.

Abilify I tried as an add-on for Parnate a few years ago and rapidly I felt worse.

The dopamine based medications you mentioned are they generally fine to take if I stay on ritalin?

> Researchers theorize that anhedonia may result from the breakdown in the brain's reward system, involving the neurotransmitter dopamine.
>
> Keeping that in mind, the drugs I'm going to recommend to you are mostly dopiminergic in nature or affect dopamine in the CNS.
>
> Mirapex and Requip are both dopamine enhancing drugs. Pramipexole(Mirapex) acts as a partial/full agonist at the following receptors: D2S receptor (Ki = 3.9 nM; IA = 130%)
> D2L receptor (Ki = 2.2 nM; IA = 70%)
> D3 receptor (Ki = 0.5 nM; IA = 70%)
> D4 receptor (Ki = 5.1 nM; IA = 42%)
> Ropinirole (Requip) acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2
>
> Nuvigil - Orexin neurons are activated by Nuvigil. Orexinergic neurons are found exclusively in the lateral hypothalamic area. Their activation is associated with enhanced pleasure-seeking and motivation as well as arousal. Orexinergic fibers project to the entire central nervous system. Its dopamine-releasing action in the nucleus accumbens is weak and dose-dependent.
>
> Rotigotine (Neupro) - has been shown effective in the treatment of anhedonia and depression. It is a dopamine agonist.
>
> Abilify is a partial dopamine agonist of the third generation class of atypical antipsychotics with additional antidepressant properties that is used in the treatment of schizophrenia, bipolar disorder, and clinical depression. Abilify is also a 5ht1a partial agonist.
>
> Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats.
>
> http://www.ncbi.nlm.nih.gov/pubmed/22327556
>
> Dextroamphetamine increases dopamine in the brain and can reverse anhedonia
>
> Ritalin (methylphenidate hcl) presumably activates the brain stem arousal system
>
> Buprenorphine can help with anhedonia
>
> Eric


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poster:AlexCanada thread:1025108
URL: http://www.dr-bob.org/babble/20120912/msgs/1025577.html