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Re: is a GABA antagonist what i need? AlexCanada

Posted by phidippus on September 12, 2012, at 17:13:11

In reply to Re: is a GABA antagonist what i need? phidippus, posted by AlexCanada on September 12, 2012, at 11:41:46

Researchers theorize that anhedonia may result from the breakdown in the brain's reward system, involving the neurotransmitter dopamine.

Keeping that in mind, the drugs I'm going to recommend to you are mostly dopiminergic in nature or affect dopamine in the CNS.

Mirapex and Requip are both dopamine enhancing drugs. Pramipexole(Mirapex) acts as a partial/full agonist at the following receptors: D2S receptor (Ki = 3.9 nM; IA = 130%)
D2L receptor (Ki = 2.2 nM; IA = 70%)
D3 receptor (Ki = 0.5 nM; IA = 70%)
D4 receptor (Ki = 5.1 nM; IA = 42%)
Ropinirole (Requip) acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D2

Nuvigil - Orexin neurons are activated by Nuvigil. Orexinergic neurons are found exclusively in the lateral hypothalamic area. Their activation is associated with enhanced pleasure-seeking and motivation as well as arousal. Orexinergic fibers project to the entire central nervous system. Its dopamine-releasing action in the nucleus accumbens is weak and dose-dependent.

Rotigotine (Neupro) - has been shown effective in the treatment of anhedonia and depression. It is a dopamine agonist.

Abilify is a partial dopamine agonist of the third generation class of atypical antipsychotics with additional antidepressant properties that is used in the treatment of schizophrenia, bipolar disorder, and clinical depression. Abilify is also a 5ht1a partial agonist.

Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats.

http://www.ncbi.nlm.nih.gov/pubmed/22327556

Dextroamphetamine increases dopamine in the brain and can reverse anhedonia

Ritalin (methylphenidate hcl) presumably activates the brain stem arousal system

Buprenorphine can help with anhedonia

Eric


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