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Re: flumazenil is probably acutely neurotoxic iforgotmypassword

Posted by SLS on September 11, 2012, at 6:36:18

In reply to flumazenil is probably acutely neurotoxic, posted by iforgotmypassword on September 11, 2012, at 2:38:31

> when given off-label it seems it's usually given with anticonvulsants to temper this. since it is used to reverse addiction, bafflingly with a number of substances (in private clinics it seems, probably for a lot of $$$), it may reverse tolerance, hence it may reverse anhedonia, fatigue and the like, if they are to be conceptualised in certain cases as being tolerant to one's own dopaminergic output, via too much glutamatergic feedback back to the system (usually from pfc i think, to the basal ganglia or vta, i forget which, i get these mixed up; in any case this mechanism in whichever way it's properly articulated is why people have experimented with memantine.)
>
> sorry this became one unbreakable sentence somehow, my attention and effort is hard to steer and going back just makes me run into obstacles in my head and makes posting harder, less likely.

All things considered, that's not a bad sentence.

:-)

I appreciate the effort it takes for you to post.

You are probably right about flumazenil being neurotoxic. If it reverses the effects of BZDs, which it does, it would allow for rebound glutamatergic hyperactivity, which is generally thought to be toxic via its ability to flood the neuron with calcium ion.

Is there any evidence that dopaminergic function is affected by flumazenil?

Have a good day.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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