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Re: is a GABA antagonist what i need? poser938

Posted by SLS on September 11, 2012, at 1:39:34

In reply to Re: is a GABA antagonist what i need?, posted by poser938 on September 11, 2012, at 0:16:40

You are not crazy - just different.

Linkadge has an annoying habit of being right most of the time. However, I have learned that there is a surprising degree of interindividual differences in the way our brains are wired and controlled chemically. Two people can react in opposite ways to the same drug. This is both fascinating and frustrating.

It occurs to me that Geodon (ziprasidone) possesses a few properties that you might be interested in, as it is a potent 5-HT2c antagonist along with being a mild-to-moderate 5-HT and NE reuptake inhibitor:

DA2 antagonist
DA3 antagonist
5-HT1a agonist
5-HT1c antagonist
5-HT2a antagonist
NE reuptake inhibition
5-HT reuptake inhibition

Also, its sister drug, Latuda (lurasidone). It doesn't block 5-HT2c receptors or inhibit the reuptake of NE and 5-HT, but adds 5-HT7 receptor antagonism - something that is now being looked at for depression.

DA2 antagonist
5-HT1a agonist
5-HT1d antagonist
5-HT2a antagonist
5-HT7 antagonist

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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