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Re: memantine success g_g_g_unit

Posted by SLS on June 1, 2012, at 3:03:16

In reply to Re: memantine success, posted by g_g_g_unit on June 1, 2012, at 2:34:07

> > I think you should wait it out a bit. I've had similar effects with MAOIs when a dosage went too high, but later, when I was used to that dosage, these effects disappeared. Depending on how much you increased your dose, you could back down a little and increase more slowly, if the sensation is too disruptive. Otherwise, I would just wait a while and see if it resolves.
> >
> > Willful
> I only increased by 5mg so I'll wait it out.
> Also, my psychiatrist agreed to add in Memantine either before or after we increase to 60mg! (Ideally before....). He said he didn't really think there was any evidence it would do much for OCD, but he didn't have any reasons against trying it. He also said he thought it would be a good augment for an MAOI, though didn't go into detail as to why .. maybe because it's cholinergic?
> I'm so happy! Mostly because I'd been terrified of asking due to tenuous evidence re: it's stimulant-tolerance-preventing properties, so overcoming that fear was a big deal for me!

I hope the memantine makes a difference for you. I had once added it to Parnate. I actually thought that it had helped. Unfortunately, I had also been switched to a generic lamotrigine (Lamictal) at about the same time. I began to deteriorate, so I discontinued the memantine before realizing that it was the generic lamotrigine that had been the culprit. I keep my bottle of memantine handy. Adding it back to my treatment regime would be the first thing I would do were my recovery to stall or poop-out. Memantine is claimed to be pro-dopaminergic by some researchers. If it is, perhaps it acts to augment Parnate as an antidepressant rather than simply prevent tolerance to its amphetamine-like effects. Memantine does several other things pharmacologically. It even increases BDNF production, which is known to be both neuroprotective and neurotrophic. Memantine might help to prevent or delay the onset of Parkinsons and Alzheimers. I think I am talking myself into trying it again.

Regarding OCD, I have encountered several studies reporting a therapeutic effect for memantine.

Good luck.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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