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Re: Scott how are you? Meds working hopefully? Alexei

Posted by SLS on May 9, 2012, at 7:01:52

In reply to Re: Scott how are you? Meds working hopefully? SLS, posted by Alexei on May 8, 2012, at 12:37:16

Hi Alexei.

> Thank you for the input. I know what you mean re: gaps in employment. That can require some "creativity", lol.
> That is good to hear re: nortriptyline. It was either that or desipramine. Yes, I have been on tricyclics before ... except I never titrated correctly ... so SE's were rough. I actually think TCA's are better than nearly all the newer drugs (AD's).

I agree. Most all of the side effects have completely disappeared for me. The two tricyclics that produce more persistent side effects are clomipramine and amoxapine.

> Nortriptyline is primarily NRI with some SRI and 5ht2a antagonism, correct?

That is an accurate summary.

> I know it hits some other 5ht... Maybe 5ht1a or 5ht2c?

Linkadge would know some of the other properties of nortriptyline.

> No, I have no reservations about it. My regime needs to be adjusted. Does nortriptyline help with sleep?

Sometimes, but not as reliably as amitriptyline, trimipramine, or doxepin. Nortriptyline can be soporific at first. This usually disappears within the first few weeks. It is probably best to take it at night begin with.

> Hope u start to feel better

Thanks, Alexei. Yesterday was an unusually good day. I remain optimistic that I will improve enough to return to work.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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