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D-amphetamine (Dexedrine; Adderal) = Serotonin? linkadge

Posted by SLS on May 2, 2012, at 7:05:49

In reply to Re: creepy, posted by linkadge on May 1, 2012, at 17:02:57

Hi Linkadge.

All in all, most of the literature I found states that amphetamine releases serotonin. You were right (as usual).

I found some referenced literature on Wiki indicating serotonin release is a property of d-amphetamine. Unfortunately, the conclusions reached in these investigations rely upon inferences based on indirect in vivo observations using pharmacological probes rather than direct in vitro measurements using synaptosomes.

The following study is interesting:

http://www.ncbi.nlm.nih.gov/pubmed/21615721

It reported actual measurements of serotonin concentrations in response to different drugs. Amphetamine was the weakest at increasing extracellular serotonin. This is not an insignificant finding. However, again, it is an in vivo measurement. It is possible that this measurement represents an indirect increase of serotonin activity resulting from negative feedback loops that are wired to attenuate hyperlocomotion

http://www.ncbi.nlm.nih.gov/pubmed/15545015

Obviously, I am cherry-picking.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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