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MAOI + Effexor = Serotonin Syndrome for me. linkadge

Posted by SLS on May 2, 2012, at 5:59:16

In reply to Re: creepy, posted by linkadge on May 1, 2012, at 17:02:57

> MAOIs have been combined safely with even SSRIs in some cases.

I have seen this reported for the reversible moclobemide - Joffe; Bakish - but not for the irreversibles Parnate and Nardil. MAOIs are weird. They are unpredictable with respect to drug and food interactions. Therefore, I wouldn't dismiss any reports of such a combination.

> I wonder if treatment resistance produces resistance to serotonin syndrome?

That's an interesting idea. For me, however, this is not the case.

One day, in great desperation, I took a very small (approximately 6.25 mg) test dose of Effexor while in the midst of Parnate treatment at 80 mg. I wanted to test for serotonin syndrome. I chose Effexor because of its relatively short half life. Within an hour of dosing, I developed the classic symptoms of SS, including muscle rigidity and an incoherent altered state. My parents said that I was saying things that were unintelligible. As I was just beginning to come out of it, I asked that they take my temperature. It was elevated by 1.5F. That is not very much, but certainly unusual for me. I can only imagine what would have happened had I taken the whole 75 mg tablet of Effexor.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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