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1) Attn: Bipolar Ultra Rapid Cyclers, 2) Diego11 Diego11

Posted by Ron Hill on April 27, 2012, at 3:33:36

In reply to Re: Agomelatine add-on to Nardil, posted by Diego11 on April 18, 2012, at 6:35:58

> Hi, I wonder, If anyone here has tried this combination with Nardil?

> I am just taking 75mg of Nardil and with 25mg of Valdoxan(agomelatine) and l am planning to go up to 50 mg.

> My doctor assumes that this combo would help me better sleeping and also help to raise/improve my low blood pressure and also he believes that agomelatine to get me the same stimulant effect as on beginning of treatment(it would supposedly help me to activate and get me back energy feeling).


I have been taking Valdoxan (agomelatine) with Nardil (phenelzine) and the rest of my combo for about 2 years with excellent results.

What is your dx? What are you attempting to treat; depression? Are you taking any other medications besides Nardil and Valdoxan? If so, what are they?

It is just my opinion, but I think you should stay at 25 mg/night of Valdoxan for more time to see if 25 is enough. I suspect 25 will do it for you. However, Id recommend that you increase your Nardil to 90 mg/day. Technically, the literature says that the effective dosage of Nardil is 1 mg of Nardil per kg of body weight. But, 90 mg/day is the dosage that often works best for patients in general.

Your p-docs belief that Valdoxan provides a stimulant effect is contrary to Section 4.8 Undesirable Effects in the Valdoxan Prescribing Information document. Section 4.8 lists somnolence, not stimulation, as a common Undesired Effect. Valdoxan caused daytime sleepiness (somnolence) for me and, therefore, I added 20 mg/day of generic Dexedrine Spanules to overcome the daytime sleepiness. Here is the link to the Valdoxan Prescribing Information document:

Further, here is the Valdoxan web site:

I can not overstate my thankfulness for Valdoxan. This medication took away my bipolar ultra rapid cycling and gave me back my life. Here is a brief discussion of my ordeal and how Valdoxan solved the problem.

About 16 years ago, an inept p-doc misdiagnosed me as ADHD and put me on Ritalin and Paxil. Since I'm bipolar, the meds caused me to become an ultra rapid cycler with a cycle of 15 days; consisting of 6 days of debilitating hellacious depression, followed by 9 days of normal mood.

The ultra rapid cycling never stopped. As soon as my 9 normal days were over, my six days of depression would start; and on-and-on non-stop for 14 years.

During the 14 years I tried various medications in an attempt to stop my ultra rapid cycling. Nothing worked until the first part of August in 2010 when I added 25 mg/night of Valdoxan (agomelatine).

When I added Valdoxan to my existing combo, my ultra rapid cycling stopped along with the related depression and hypomania.

Since I began taking Valdoxan roughly two years ago, I have been in full remission, with the caveat that in addition to taking all of my meds, I must also take my vitamins and supplements.

If I do not take my vitamins and supplements daily, I become depressed. No ultra rapid cycling, but a moderate depression consisting primarily of amotivation.

Below is a list of my meds, and my vitamins and supplements.

-- Ron


200 mg/day lamotrigine

600 mg/day oxcarbazepine

500 mg/day Keppra

90 mg/day Nardil

20 mg/day Dexedrine spanules

7.5 mg/day Deplin

25 mg/day Valdoxan (agomelatine)

Vitamins and Supplements:

5000 mcg/day of sublingual methylcobalamin

25 mg/day of sublingual P-5-P

850 mg/day of Mg 212% of RDA (as 5 grams of Mg Malate)

One Multi-vitamin/day; Only 100% of all the usual vitamins; Look for good chelations. NO VANADIUM!!

60 ml/day (= cup) of Bottled Fish Oil

200 mg/day phosphatidylserene

2000 IU/day Vitamin D-3

600 mcg/day Chromium Picolinate

200 mcg/day GTF Chromium

1000 mg/day Cinnamon

600 mg/day N-Acetyl-L-cysteine (NAC)

250 mg/day Acetyl-L-Carnitine

300 mg/day Alpha-Lipoic Acid

500 mg/day L-Arginine

200 mg/day Co-Q10

2 g Vitamin C

8 to 10 glasses of water





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