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Re: Adding Parnate and prazosin. phidippus

Posted by SLS on April 3, 2012, at 20:40:58

In reply to Re: Adding Parnate and prazosin. SLS, posted by phidippus on April 3, 2012, at 18:44:29

> Its upregulating dopamine! How is it killing your sex drive???

I really don't know, but I'm not particularly happy about it.

Reduced libido is uncommon with prazosin from what I understand. You will find it described on some drug lists, though. I began looking into this only after I recognized a major reduction in sexual appetite. If this is as bad as side effects get for me, it is worth the trade-off. I am hoping that I will recoup some libido as the depression evaporates.

In certain areas of the brain, NE alpha-1b receptors act as a gate to allow throughput for dopamine circuits afferent to the limbic system. Closing the gate by blocking these receptors serves to attenuate the increased locomotor activity produced by psychostimulants like cocaine. I don't know if this is also true of appetitive drives and cravings.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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