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Re: is buspar or remeron more powerful on serotonin? mogger

Posted by SLS on March 26, 2012, at 13:10:19

In reply to Re: is buspar or remeron more powerful on serotonin? SLS, posted by mogger on March 26, 2012, at 12:28:37

> Thanks Scott. It is interesting as I checked and I did an interaction checker with mirtazapine and zoloft and then buspar and zoloft separately and the interaction between buspar and zoloft was (serious: use alternative) and the interaction between zoloft and remeron was (moderate: monitor closely). Both these interactions stated that there was increase in serotonin but I am not sure why the buspar and zoloft interaction is more significant.

I believe this warning regarding a Buspar and Zoloft combination is based upon theory - and a rather flawed one. The concern revolves around the ability for Buspar to act to partially stimulate serotonin 5-HT1a receptors. Combining 5-HT reuptake inhibition and 5-HT1a receptor partial agonism is precisely what Viibryd is all about. Viibryd has not yet demonstrated a propensity to produce serotonin syndrome. Buspar is often chosen to augment serotonergic drugs. If it were so dangerous to do this, we would have seen more of it. Actually, Buspar has its own "safety valve" to prevent overstimulation. It not only acts on postsynaptic receptors, but on presynaptic autoreceptors as well. I think of Buspar as being more of a serotonin modulator than a stimulator.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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