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Re: any namenda/memantine experiences? novelagent

Posted by SLS on March 11, 2012, at 13:47:32

In reply to Re: any namenda/memantine experiences? g_g_g_unit, posted by novelagent on March 11, 2012, at 13:18:39

> try galantamine with 1gram of CDP Choline twice a day. In clinical trials for schizophrenia, this combo was effective as a cognitive enhancer-- which has failed as monotherapy in the past.

That's interesting. Thanks for the information.

It seems that galantamine enhances dopamine release in the VTA via nicotinic receptor potentiation. This effect is separate from its ACh cholinesterase inhibition. The nicotinic receptor effects occur at a lower dosage than enzyme inhibition. Perhaps lower dosages will prove sufficient to treat depression. This is good because cholinesterase inhibitors can be depressogenic. Less might be more.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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URL: http://www.dr-bob.org/babble/20120302/msgs/1012806.html