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Re: Adding Parnate and prazosin. sigismund

Posted by SLS on March 4, 2012, at 6:10:33

In reply to Re: Adding Parnate and prazosin. SLS, posted by sigismund on March 3, 2012, at 21:42:27

Hi Sigi.

15% is better than zero, I'm sure we could both agree. It allowed me to live independently instead of with my parents or a supportive residence. That 15% was primarily the product of combining nortriptyline and Lamictal. Everything else that I took at any one time was for the purpose of experimentation rather than as a treatment to commit to. Bringing in Abilify helped a bit - enough for me to choose to remain on it while searching for other things. Adding an MAOI to a TCA is what got me well the first time in 1987. So adding Nardil or Parnate to the nortriptyline was a no brainer unless I wanted to try something novel. For me, novel meant anything different than I had thusfar tried. For instance, I tried Lexapro. It didn't help. However, Celexa remains novel to me as my brain has never seen it before, despite the molecular similarities. Anyway, I brought lithium on board for its neurogenesis and neuroprotection. Unexpectedly, in combination with Parnate, it helped to smooth out "mood drift". It helped stabilize me and enhanced the antidepressant effects to the other drugs I was taking. That's five drugs. I added prazosin. That's six.

When I remove ANY ONE of the drugs I take, I relapse.

This logical progression of determining drug treatment is more than just a haphazard throwing of enough sh*t against the wall to see how much would stick. I hope you can understand why I felt somewhat insulted by your words. In a way, they were an insult to my intelligence and that of my doctors as well. I guess that is really my problem and not yours.

My sleep is significantly smoother for having added prazosin. I experience fewer awakenings. Experiments have shown that prazosin and clonidine each increase the spectral power of delta-wave (slow-wave) sleep as seen on an EEG. This should produce a greater period of time spent in deep sleep. I hope prazosin helps you.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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