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Re: Latuda? Solstice

Posted by SLS on January 14, 2012, at 19:10:01

In reply to Re: Latuda? SLS, posted by Solstice on January 14, 2012, at 9:33:31

> I'm so glad you responded, Scott..

> > I'm sure you know that Latuda is closely related to Geodon.

> I knew it was in the same class, but that's about it. :-)

> > It is an interesting choice.
>
> Can you elaborate? What are your thoughts?

Latuda retains most of the properties of Geodon, but loses the NE and 5-HT reupake inhibition that acts like an antidepressant. It adds 5-HT7 blockade, which might be good to improve cognition, memory, and depressive symptoms.

Geodon and Latuda both produce brain fog in me, which becomes more prominent at higher dosages.

> > Just be sure to take Latuda with food as you did with Geodon.

> What happens if it's not taken with food?

You don't get the full blood level. You can lose as much as 50%.

> Does it need to be a full meal?

500 calories is recommended.

> > Latuda is probably less activating than Geodon.

> I'm not sure what 'less activating' means?

For some people, it means an increase in constructive psychic energy. For others, it means an increase in agitation.

Geodon is generally weight-neutral. I am guessing that Latuda is, too.

Saphris (asenapine) does many of the same things as Latuda, but without the 5-HT1a partial agonism. It might be less apt to provoke agitation.

With Geodon, I experienced a significant reduction in depression during the first week of treatment. Thereafter, nothing. I actually added Latuda to Abilify. It didn't help with depression.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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poster:SLS thread:1007178
URL: http://www.dr-bob.org/babble/20120108/msgs/1007250.html