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Re: my research: parnate vs nardil floatingbridge

Posted by europerep on June 12, 2011, at 16:13:27

In reply to my research: parnate vs nardil, posted by floatingbridge on June 11, 2011, at 2:54:54

Hey FB...

> Parnate is actually a form of amphetamine (or a close cousin).

True. It is structurally related, and it has about 1/10th of the potency of amphetamine as a dopamine and norepinephrine releasing agent. This makes that, especially in the beginning, Parnate has a mild stimulant-like effect.
This probably accounts for some of the "Parnate insomnia", though I guess that insomnia is also partially caused by the same mechanism as insomnia in SSRIs, i.e. more serotonin stimulation.

> Parnate has anixoltic qualities, but not as great as nardil.


> Parnate carries a higher risk factor (intercranial bleeding)?

Parnate does appear to be slightly more dangerous, yeah. I've been told by an "MAOI expert" that Parnate is the most dangerous of MAOIs, though, absolutely speaking, it is still a safe drug. Part of the risk is due to spontaneous hypertensive episodes, as jedi mentioned.

As for the intracranial bleeding: there must be (at least) two factors for it, a predisposition for it and a sharp rise in blood pressure. Predisposition in the sense that a vein or a blood vessel in the head is "faulty". In case of a sudden rise in blood pressure, that vein or blood vessel may pop and then lead to a bleeding. I'd think this can happen anywhere in the body, but in the brain it's a big problem. However, this is rare and it can't happen to everyone.

> Nardil has a less direct amphetamine like effect. Will it always be more sedating? 24/7?

I think Nardil is structurally very different, and does not have any amphetamine-like qualities, though I may be wrong.

> Parnate insomnia is more intractable than nardil insomnia.

Parnate insomnia is definitely more frequent, and probably more difficult to treat. Taking doses early in the day helps for some, but not for all.
Trazodone is what they usually use in the US to deal with it, as far as I have heard.

Looking back, to me, Parnate was just like any other drug. Yes, also in the sense that it didn't work, but you forget that you're on an MAOI after a few weeks. Well, not totally forget, but you're no longer scared or afraid or something might happen. I checked my BP often in the first weeks, but when I noticed that it never rose I limited it to "after eating something I hadn't eaten the weeks before".

Hope this helps!





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