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Re: my research: parnate vs nardil

Posted by hyperfocus on June 11, 2011, at 18:03:43

In reply to Re: my research: parnate vs nardil, posted by Christ_empowered on June 11, 2011, at 7:34:04

>I read somewhere that something--low dose elavil, maybe?--can be added to ongoing MAOI therapy to minimize the risk of the "cheese reaction."
Administration of amitriptyline greatly diminished the pressor response to intravenous tyramine in patients receiving monoamine-oxidase inhibitors (MAOIs). Dothiepin and trimipramine, however, produced little change in sensitivity to tyramine. It is suggested that a combination of amitriptyline and an MAOI, started together in a modest dose that is then increased, may protect patients against the potential dangers of eating tyramine-containing foods. However, because MAOIs allow a high proportion of ingested tyramine to be absorbed into the systemic circulation, patients treated with MAOIs, even in combination with amitriptyline, should not be encouraged to eat foods containing tyramine.

There are a couple of studies like this. fb if the EMSAM causes you sleep issues then it's highly likely Parnate would too. So I guess the best tack would be attacking the insomnia before you decide to switch MAOIs. I know I keep banging away at the same drum but there are a lot of reasons why amitrip would be a good match for you. The biggest SE of amitriptyline is sedation, which would be beneficial to you.

C-PTSD: social phobia, major depression, dissociation
Currently on 150mg amitriptyline single dose at night.




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