Psycho-Babble Medication | about biological treatments | Framed
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Re: To Cheryl-Lynne Anhedonia

Posted by ggggg123 on November 2, 2010, at 6:34:46

In reply to Re: To Cheryl-Lynne Anhedonia, posted by Conundrum on October 31, 2010, at 18:01:40

I am definately starting to feel alot better, taking the 1.25mg of bromo and I've been taking a little bit of bupropion, defo seems to be a norep and dopa thing, today I have a doctors appointment and I'm going to ask to start reboxetine, as its an nri and bupropion is'nt available over here. I am thinking nri low dose combined with small amount of bromo and exercise/getting out and about, today I feel like going out for the first time in a while, which is how I used to feel before I went into hibernation.

I'm not going to try to antagonize the 5ht2c receptor as, when i took mirt all i wanted to do was eat and sleep, I believe you are right about the nor and dop drugs, my problem really seems to be a pure norep and dop deficiency, basically a depression, which could stem from the original symptoms prior to using an ssri and have later been attenuated by the serotonergic properties of the drug. Also most tca's are serotonergic aswell, which I really do want to avoid, its is said that norep increases serotonin indirectly, pesonally I think it increases both serotonin and dopamine, and can be very useful, where as serotonin seems to diminsh the other neurotransmitters. I know I have a norepinephrine deficiency, because I no longer get nervous or excited, I used to be fairly nervous and felt quite alot of emotion, since my anhedonia I have felt non. I think long term nri therapy at a reasonably low dose could be the best strategy for a subgroup of people wo do not improve after ssri therapy. Adding a small amount of a dopamine agonist may also be very useful. Theres a section on the good drug guide at biopsychiatry . c o m which talks about reboxetine, I don't know how it will compare to bupropion as its also twice a day dosing. But honestly I am feeling so much better now I can feel some norepinephrine and dopamine in my brain, it makes you feel content and almost half way to happy.




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