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Re: Diphenhydramine contra-indications?

Posted by ed_uk2010 on October 9, 2010, at 9:59:00

In reply to Re: Diphenhydramine contra-indications?, posted by medamorphosis on October 9, 2010, at 9:13:56

>Perhapse the added antihistamine effect did make me sleep slightly deeper after the second dose, or maybe diphenhydramine's mild SRI effect helped the quality of my sleep, at least to a managable degree(?) Apart from the usual boredom my mood has been ok-ish today.

Perhaps the anticholinergic effect reduced the dreaming.

>BTW question for ed: You say UK is out of stock. Does that mean it is simply 'currently' out of stock, or is it actually no longer available in the UK?

As far as I know, MSD (the manufacturer) isn't releasing any Periactin into UK wholesalers at present. They either have no stock or very little stock. Periactin has not been officially discontinued in the UK, although I wouldn't be surprised if MSD does decide to discontinue it in the near future - it can't be very profitable, the price is low and it's very rarely prescribed. As an alternative to discontinuation, MSD might decide to divest Periactin to another pharma company. There are a handful of small pharma companies whose business model revolves around acquiring the rights to niche brands which are no longer of interest to big pharma.

There is no generic cyproheptadine in the UK. Generics manufacturers aren't usually interested in such rarely used products unless they can sell at a high price. They probably wouldn't be able to sell Periactin at a high price because doctors would stop using it altogether.




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